Error - prone Replication Bypass of the Primary Aflatoxin B 1 DNA

Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations

Molecular insights into error-prone DNA replication and error-free lesion bypass.

6·4 pp CPD error propensity when dealing with undamaged DNA, which distinguishes them from known high-fidelity DNA polymerases. Most of their biological roles and functions have not been elucidated yet. Nevertheless, recent investigations suggest the involvement of pol L together with poll;, in error-prone translesion DNA synthesisPJ Furthermore, it has been shown that pol L possesses lyase act...

DNA polymerases f and Rev1 mediate error-prone bypass of non-B DNA structures

DNA polymerase f (Pol f) and Rev1 are key players in translesion DNA synthesis. The error-prone Pol f can also participate in replication of undamaged DNA when the normal replisome is impaired. Here we define the nature of the replication disturbances that trigger the recruitment of error-prone polymerases in the absence of DNA damage and describe the specific roles of Rev1 and Pol f in handlin...

DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures

DNA polymerase ζ (Pol ζ) and Rev1 are key players in translesion DNA synthesis. The error-prone Pol ζ can also participate in replication of undamaged DNA when the normal replisome is impaired. Here we define the nature of the replication disturbances that trigger the recruitment of error-prone polymerases in the absence of DNA damage and describe the specific roles of Rev1 and Pol ζ in handlin...

Involvement of Rad18 in somatic hypermutation.

Somatic hypermutation of Ig genes is initiated by transcription-coupled cytidine deamination in Ig loci. Error-prone processing of the resultant DNA lesions is thought to cause extensive mutagenesis, but it is presently an enigma how and why error-prone rather than error-free repair pathways are recruited. During DNA replication, recruitment of error-prone translesion polymerases may be mediate...